Pharmacodynamics & Kinetics
Pharmacokinetics describes what the body does to a drug: absorption, distribution, metabolism and excretion (ADME).
Pharmacology
10 notes
Notes 10
Autonomic Drugs
The autonomic nervous system regulates smooth muscle, cardiac muscle and glands. All autonomic preganglionic neurons release acetylcholine onto nicotinic neuronal (Nn) receptors.
CVS & Renal
MCQ tip: Thiazides reduce urinary calcium excretion; loop diuretics increase it. Heparin-induced thrombocytopenia (HIT) is important because it causes thrombocytopenia with a paradoxically increased…
Anti Microbials
Coverage varies by individual drug; generation alone does not predict all susceptibility. Dental exam tip: Clindamycin is associated with C.
Analgesics
Dental relevance: NSAIDs are useful for inflammatory dental pain when suitable; paracetamol is an alternative or adjunct. Choose according to the patient's medical history and contraindications.
CNS
Antidote: Naloxone, with repeat dosing or infusion when needed because some opioids outlast naloxone. May occur with combinations of serotonergic drugs.
Anesthesia
General anesthetics produce reversible unconsciousness and other components of anesthesia, such as amnesia and immobility.
Emergencies
Important: Flumazenil can precipitate seizures in benzodiazepine-dependent patients or mixed overdoses; it is not a universal antidote for an unconscious patient.
Last Day Revision
A prodrug is a pharmacologically inactive (or weakly active) compound that is converted into an active, functional drug inside the body after administration.
